STAGE III / 2019: In vitro demonstration and evaluation of the functionality of 3D stem cells-matrix systems in the treatment of complex lesions of oral tissue
Activities
III.1. Screening of cell differentiation and adhesion capacity and establishing the optimal cultivation parameters – Part II
III.2. Evaluation of DPSC secreted factors on the synthesis of new ECM.
III.3. Demonstration of 3D stem cell-matrix system functionality and utility for treatment of complex oral tissue conditions
III.4. Dissemination of results, webpage and reporting
III.5. Documentation for patent demand
III.6. Project management
Stage III results
- Optimized experimental models for structural analysis of 3D cell culture systems
- Lab technology for obtaining matrix-stem cells 3D systems
- Functional variants of matrix-stem cells 3D systems
Stage III summary
Dissemination of results
Article
Seciu AM., Craciunescu O., Stanciuc AM., Zarnescu O. 2019. Tailored biomaterials for therapeutic strategies applied in periodontal tissue engineering. Stem Cells and Development. vol. 28, no. 15, 963–973. [Link]
Patent application
OSIM no. A/00454 / 26.07.2019. Zarnescu O., Craciunescu O., Seciu AM., Moldovan L., Gaspar-Pintiliescu A., Stanciuc AM., Stefan LM. Biopolymeric composite hydrogel for treatment of periodontal disease and process for obtaining thereof.
Conferences
Zarnescu O., Seciu AM., Craciunescu O., Moldovan L. Multilineage differentiation capacity of human dental pulp stem cells cryopreserved for regenerative medicine applications. European Biotechnology Congress, April 11-13, 2019, Valencia, Spain. Published in J. Biotechnology, 2019, 305, Supplement, p. S85. [Link]
Seciu AM., Craciunescu O., Stan L., Zarnescu O. 2019. Anti-inflammatory activity of biomaterials intended for periodontal disease treatment. PRIOCHEM 15th edition, 30 oct – 1 nov 2019, Bucharest, Romania. Published in MDPI Proceedings 2019, 29 (1), p. 66 [Link]